So at three weapons each, I'm looking at needing around 18 weapon slots to facilitate the various load-outs, assuming they each use different weapons. Right now I'm at six warframes not counting the quest frames, as those are exceptions. Generally I plan to have load outs for all my warframes. Do I enjoy playing/using the warframe/weapon ? If the answer to the first question is yes then I ask myself question 2, which is Do I see myself using this weapon, or coming back to it ? if answered no on this question then its not put on my list. Normally I ask myself two questions when looking at warframes and weapons. With the other warframes its on a case by case bases. This is mostly due to the fact these warframes can't be reacquired, since there quest aren't re-playable.
What I personally do is that I have a warframe slot for each of the quest frames so Chroma, Mirage, Limbo, Atlas. It varies from player to player on what they do when it comes to slots for weapons, and warframes.